Efficient FPSoC Prototyping of FCS-MPC for Three-Phase Voltage Source Inverters

This work describes an efficient implementation in terms of computation time and resource usage in a Field-Programmable System-On-Chip (FPSoC) of a Finite Control Set Model Predictive Control (FCS-MPC) algorithm. As an example, the FCS-MPC implementation is used for the current reference tracking of a two-level three-phase power converter. The proposed solution is an enabler for using both complex control algorithms and digital controllers for high switching frequency semiconductor technologies. An original HW/SW (hardware and software) system architecture for an FPSoC is designed to take advantage of a modern operating system, while removing time uncertainty in real-time software tasks, and exploiting dedicated FPGA fabric for the most complex computations. In addition, two different architectures for the FPGA-implemented functionality are proposed and compared in order to study the area-speed trade-off. Experimental results show the feasibility of the proposed implementation, which achieves a speed hundreds of times faster than the conventional Digital Signal Processor (DSP)-based control platform.Ministerio de Economía y Competitividad TEC2016-78430-RFondo Nacional de Investigación de Qatar NPRP 9-310-2-13

Thin film nanostructuring at oblique angles by substrate patterning

It is demonstrated that, besides classical nanocolumnar arrays, the oblique angle geometry induces the growth of singular structures in the nanoscale when using wisely designed patterned substrates. Well-ordered array of crosses, cylindrical nanorods or hole structures arranged in square or hexagonal regular geometries are reported as examples, among others. The fundamental framework connecting substrate topography and film growth at oblique angles is presented, allowing the use of substrate patterning as a feasible thin film nanostructuring technique. A systematic analysis of the growth of TiO2 thin films on 4 different lithographic patterned substrates in 4 different scale lengths is also presented. A first conclusion is the existence of a height-based selective growth in the initial stages of the deposition, by which the film preferentially develops on top of the tallest substrate features. This behavior is maintained until the film reaches a critical thickness, the so-called Oblivion Thickness, above which the film topography becomes gradually independent of the substrate features. A general formula relating the spatial features of the pattern, the coarsening exponent and the Oblivion Thickness has been deduced.MCIN/AEI/and FEDER project PID2019-110430GB-C21MCIN/AEI/ and FEDER project PID2020-112620GB-I00MCIN/AEI/ and FEDER project PID2020-114270RA-I00MCIN/AEI/ and FEDER project RTI2018-098117-B-C21Junta de Andalucía PAIDI-2020 project P18-RT-3480Junta de Andalucía PAIDI-2020 project P18-RT-6079University of Seville VI PPIT-U

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Regreso a la cueva de El Morrón (Torres, Jaén): revisión arqueológica treinta y cinco años después de su descubrimiento

En este artículo presentamos el estudio arqueológico desarrollado en el marco de la Actividad Arqueológica Puntual de “Diagnóstico destinado a la preservación y propuesta de medidas correctoras para la conservación de la cueva de El Morrón (Torres, Jaén)” (2014-2015). La metodología aplicada ha consistido en la revisión sistemática de la totalidad de las superficies endokársticas, tanto parietales como pavimentarias, la documentación arqueométrica y catalogación de los restos arqueológico, tanto conocidos como inéditos, haciendo especial hincapié en su estado de conservación; la documentación fotográfica, la restitución gráfica mediante el tratamiento digital de las evidencias rupestres (calcos) junto con el análisis cronológico de todas evidencias de frecuentación desde una perspectiva estilística (motivos figurativos parietales) como radiométrica (datación de un resto óseo). En el piso de la cueva hemos detectado varios fragmentos de cerámica tanto a mano como a torno, una lasca de sílex y varios restos óseos, algunos humanos, junto con una acumulación antrópica de bloques y tierra. El repertorio gráfico de la cueva, aunque sigue siendo muy escueto, se ha ampliado con la representación parcial de un posible zoomorfo, varias manchas rojas y trazos negros. También presentamos la datación C14-AMS de uno de los restos óseos humanos. Asimismo, hemos constatado un importante deterioro de los figuras paleolíticas conocidas